Targeted sequencing provides a time and cost-effective workflow by investigating specific regions in the genome. Hybrid capture-based target enrichment employs probes to capture target sequences in a NGS library. Hybrid capture sequencing is sensitive and suited for detecting single nucleotide variants, translocations, structural variants, insertions and deletions, and copy number variations. Agilent provides a full suite of hybridization capture-based target enrichment NGS products, including library preparation and target enrichment kits, exomes, catalog and custom probes, software solutions, sample quality control and automation platforms. Whether your research needs a catalog NGS panel or a custom design to include your genes of interest, Agilent has the solutions for you. Agilent offers other amplicon-based target enrichment technology options, also, for finding specific regions-of-interest time. 




Targeted sequencing provides a time and cost-effective workflow by investigating specific regions in the genome. Hybrid capture-based target enrichment employs probes to capture target sequences in a NGS library. Hybrid capture sequencing is sensitive and suited for detecting single nucleotide variants, translocations, structural variants, insertions and deletions, and copy number variations. Agilent provides a full suite of hybridization capture-based target enrichment NGS products, including library preparation and target enrichment kits, exomes, catalog and custom probes, software solutions, sample quality control and automation platforms. Whether your research needs a catalog NGS panel or a custom design to include your genes of interest, Agilent has the solutions for you. Agilent offers other amplicon-based target enrichment technology options, also, for finding specific regions-of-interest time. 




SureSelect XT HS2 DNA Reagent Kit

Agilent SureSelect XT HS2 DNA reagent kit is a state-of-the-art NGS library preparation and target enrichment solution. It provides a streamlined and flexible workflow, excellent performance, and comprehensive features that can be used in various NGS applications. 

Features:

  • Generate high-quality libraries with as little as 10 ng of DNA input from intact or highly fragmented FFPE DNA 
  • 90-minute fast hybridization enable single day workflow from DNA sample to Sureselect-enriched libraries 
  • Use single/duplex molecular barcodes (MBC) to remove false positives and accurately detect variants down to ≤1% variant allele frequency 
  • Minimize index hopping with 384 unique dual indexing 
  • Simplify your order experience with option to include enzymatic fragmentation kit and beads for clean-up & hybrid-capture 
  • Use with SureSelect exomes, catalog panels or easily create custom panels with the SureDesign software
  • Compatible with Pre-Capture pooling protocol for ease of processing large batch of sample 

SureSelect Human All Exon

Agilent SureSelect Human All Exon V7

The Agilent SureSelect Human All Exon V7 delivers unmatched coverage of targeted regions with minimal sequencing. Designed using the GRCh38/hg38 genome assembly, this exome design targets coding regions from RefSeq, CCDS, GENCODE &USC Known Genes. All exon sequencing product features a novel bait design algorithm resulting in an end-to-end design size of only 48.2 MB. 

  • With just 5.3 GB of sequencing, the SureSelect Human All Exon V7 provides 20x coverage of >94% of targeted bases
  • Excellent overall uniformity and percent on-target enable variant calling with high confidence while reducing sequencing costs 
  • Targets protein coding regions from RefSeq, GENCODE, CCDS and UCSC known genes, including hard-to-capture exons that are omitted from other exomes 
  • Targets all pathogenic variants in the genes included in the ACMG guidelines for secondary findings 
  • The raw data generated from human all exon sequencing can be readily analyzed using the Agilent Alissa Clinical Informatics Software, solving the data analysis bottleneck.  

SureSelect Cancer All-in-One (AIO)

SureSelect Cancer AIO assays are a revolutionary new type of NGS assay. They enable you to detect single nucleotide variants (SNVs), indels, copy number variants (CNVs), and translocations in a single DNA assay.  These assays include either catalog or custom panels (created using the SureDesign tool), the SureSelect XT HSv2 for NGS library preparation, and complementary SureCall software for data analysis forms the comprehensive workflow solution for high-sensitivity genomic variant detection in cancer research. 

Sureselect Cancer AIO Assay available:

  • SureSelect Cancer All-In-One Lung Assay surveys 20 genes clinically relevant to nonsmall cell lung cancer (NSCLC). It includes all somatic variants associated with NSCLC in the guidelines of the National Comprehensive Cancer Network (NCCN), the College of American Pathologists (CAP), and the European Society for Medical Oncology (ESMO).
  • SureSelect Cancer All-In-One Solid Tumor Assay profiles 98 genes relevant to multiple common solid tumor types, including lung, breast, ovarian, colorectal, prostate, sarcoma, and skin
  • SureSelect Cancer All-In-One Custom. Design your Sureselect panel targeting somatic SNV, indel, CNV and translocation of your gene of interest using the SureDesign web portal 

SureSelect Custom Design

Enabled by the SureDesign custom design tool, you can design and order any custom panel within minutes. Combine your custom panel with one of the OneSeq CNV backbones to achieve a comprehensive solution to detect SNVs, indels and CNVs in one workflow. 

Visit Agilent SureDesign portal to start creating your SureSelect panel or contact us for a free consultation 

Magnis NGS Prep System

The Magnis system provides a complete system for NGS library preparation that is fully automated. This system works seamlessly with Agilent’s industry-leading SureSelect target enrichment system and delivers sequencing data that are robust, traceable, and reproducible.

This benchtop instrument self-detects and tunes; the reagents are provided pre-aliquoted; and the system comes with pre-set protocols for Agilent’s catalog and custom assays making it easy to assay multiple genes and complex genetic aberrations from genomic DNA including degraded samples such as formalin-fixed paraffin embedded (FFPE).  

Take a Quick Tour on the Magnis System

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